NSCLC metastatic/no molecular target

Ongoing protocols: click on the protocol for the inclusion and exclusion criteria (update 10/07/2018)

1st line
ELEVATION (Novartis)
Phase Ib, multicenter, open label study of PDR001 in combination with platinum-doublet chemotherapy in PD-L1 unselected, metastatic NSCLC patients.
(currently cohort non-squamous on hold)

A Study of Nivolumab plus Ipilimumab in Combination with Chemotherapy vs Chemotherapy alone as First Line Therapy in Stage IV Non-Small Cell Lung Cancer (NSCLC).

BFAST (Roche)
A phase II/III multicentre study evaluating the efficacy and safety of multiple targeted therapies as treatments for patients with advanced or metastatic non-small cell lung cance (NSCLC) harbouring actionable somatic mutations detected in blood (B-Fast: blood-first assay screening trial).

IPSOS (Roche)
A phase III, open-label, multicenter, randomized study to investigate the efficacy and safety of atezolizumab compared with chemotherapy in patients with treatment-naïve advanced or recurrent (stage IIIB not amenable for multimodality treatment) or metastatic (stage IV) non-small cell lung cancer who are deemed unsuitable for platinum-containing therapy.

2nd line
RO6874281 (Roche)
An open-label, multicentre, phase II study to evaluate the therapeutic activity of RO6874281, an immunocytokine, consisting of interleukin-2 variant (IL-2V) targeting fibroblast activation protein-A (FAP), in combination with atezolizumab (anti-PD-L1), administered intravenously, in participants with advanced and/or metastatic sold tumors.
(currently cohort A on hold)

3th line 
Currently no trials

New trial in start-up: currently no new trials